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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease li-fraumeni syndrome
Comorbidity C0022602|actinic keratosis
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PubMedID- 25906193 In addition to aging it is well known that uv-irradiation induces mutations in the tumor suppressor p53 leading to actinic keratosis in a first step, that can further develop to skin cancers [34].

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